Info Pgk
US 3 058 882 Hoechst 16.10.1962 D-prior. 28.12.1959 . DE 1 122 541 Hoechst appl. 28.12.1959 . DEI 213 846 Hoechst appl. 13.4.1963 . DE 1 220 436 Hoechst appl. 21.10.1964 . DE 1 277 860 Hoechst appl. 4.5.1966 . DE 1 295 566 Hoechst appl. 23.3.1968 . DAS 1 806 581 Hoechst appl. 2.11.1968 . Sturm, K. et al. Chem. Ber. CHBEAM 99, 328 1966 . Formulation s amp. 80 mg, 500 mg s. r. cps. 30 mg, 60 mg, 120 mg sol. 20 mg, 40 mg, 50 mg, 250 mg as sodium salt tabl. 20 mg, 25 mg, 40 mg
Ch Rbq
bephenium chloride I sodium 3-hydroxy- US 2 918 401 Borroughs Wellcome 22.12.1959 GB-prior. 29.3.1956 . DE 1 117 600 Wellcome Found. appl. 21.3.1957 GB-prior. 29.3.1956, 24.1.1957 . Formulation s gran. 2.5 g, 4.33 g powder 5 g D Alcopar Wellcome wfm J Alcopar-P Wellcome- USA Alcopara Borroughs F Alcopar Wellcome wfm Tanabe Wellcome wfm Use calcium channel blocker, antianginal RN 64706-54-3 MF C24H34N20 MW 366.55 EINECS 256-384-7 LD50 1955 mg kg M, p.o. 23,5 mg kg M, i.v. RN 68099-86-5 MF...
ChlorpromazineATC nosaaoi
Use antipsychotic, neuroleptic, psychosedativc RN 50-53-3 MF CnH19ClN2S MW 318.87 EINECS 200-045-8 LD50 16 mg kg M, i.v. 135 mg kg M, p.o. 23 mg kg R, i.v. 142 mg kg R, p.o. 30 mg kg dog, i.v. CN 10-propanamine RN 69-09-0 MF C17H19C1N2S HCl MW 355.33 EINECS 200-701-3 LD50 20 mg kg M, i.v. 135 mg kg M, p.o. 25 mg kg R, i.v. 145 mg kg R, p.o. US 2 645 640 Rh ne-Poulenc 1953 F-prior. 1950 . DE 910 301 Rh ne-Poulenc appl. 1951 F-prior. 1950 . Formulations amp. 25 mg ml, 50mg 2 ml drops 20 mg ml...
Cooh Fsa
1 -methyl-indazole-3-carboxylic acid 1 -methyl-indazole-3-carbonyl chloride 1 -methyl-indazole-3-carbonyl chloride
Ho Ebs
Arcamone, F. et al J. Med. Chem. JMCMAR 18, 703 1975 . DOS 2 510 866 Farmitalia appl. 20.3.1975 GB-prior. 22.3.1974 . US 4 058 519 Farmitalia 15.11.1977 appl. 19.3.1975 GB-prior. 22.3.1974 . DOS 2 618 822 Farmitalia appl. 29.4.1976 GB-prior. 30.4.1975 . purification GB 2 133 005 Farmitalia appl. 16.12.1983 . Formulation s vial 10 mg, 20 mg, 50 mg as hydrochloride Trade Name s D Farmorubicin Pharmacia GB Pharmarubicin Pharmacia J Farmorubicin Farmitalia amp Upjohn 1984 amp Upjohn 1985 F...
Hohoho J Oh 0 Oh
Zempten, G. Bogn r, R. Ber. Dtsch. Chem. Ges. BDCGAS 76, 452 1943 . Lorette, N.B. et al. J. Org. Chem. JOCEAH 16, 930 1951 . Horowitz, R.M. J. Org. Chem. JOCEAH 21, 1184 1956 . DOS 2 602 314 Hommel appl. 22.1.1976 CH-prior. 16.5.1975 . Formulation s cps. 300 mg cream4 g 100 g tabl. 150 mg Dio Labs. Scienex Diosmil Rh ne-Poulenc Rorer Endium Labs. Europhta Flebosmil Socopharm Litosmil Evans Medical M diveine Elert Pr paration H Veinotonic Whitehall I Arvenum Stro.der Daflon Servier Diosven CT...
Ho Fqr
DOS 2 117 826 Reckitt amp Colman appl. 13.4.1971 GB-prior. 14.4.1970 . GB 1 308 327 Reckitt amp Colman valid from 19.4.1971 prior. 14.4.1970 . US 3 766 263 Reckitt amp Colman 16.10.1973 GB-prior. 14.4.1970 . GB Flenac Recki tt amp Colman wfm RN 13042-18-7 MF c23H25n MW 315.46 einecs 235-915-6 CN RN 13636-18-5 MF C23H25N HCl MW 351.92 EINECS 237-121-5 LDS0 14.5 mg kg M, i.V. 95omg kg M, p.o. DE 1 171 930 Chinoin appl. 24.7.1962 H-prior. 10.8.1961, 10.3.1962, 19.3.1962, 30.3.1962 . US 3 262 977...
O Rsc
IV V D - -threo-2-dichloro-acetamido-1 - 4-nitro-phenyl -1,3-propane-dial dinitrate D - -threo-2-dichloro-acetamido-1 - 4-nitro-phenyl -1,3-propane-dial dinitrate a Long, L.M. Troutman, H.D. J. Am. Chem. Soc. JACSAT 71, 2469, 2473 1949 . US 2 483 871 Parke Davis 1949 appl. 1948 . US 2 483 884 Parke Davis 1949 appl. 1948 . US 2 483 885 Parke Davis 1949 appl. 1949 . US 2 483 892 Parke Davis 1949 appl. 1948 . US 2 687 434 Parke Davis 1954 appl. 1953 . US 2 651 661 Monsanto 1953 appl. 1950 . US 2...
N Cnd
DE 2 915 318 Angelini appl. 14.4.1979 I-prior. 18.4.1978 . US 4 307 095 Angelini 22.12.1981 prior. 29.3.1979, 29.8.1980 I-prior. 18.4.1978 . US 4 307 096 Angelini 22.12.1981 prior. 29.3.1979, 29.8.1980 I-prior. 18.4.1978 . US 4 325 952 Angelini 20.4.1982 prior. 29.3.1979, 29.8.1980 I-prior. 18.4.1978 . BE 877 161 Angelini appl. 21.6.1979 . EP 288 659 Angelini appl. 25.1.1988 . US 4 879 294 Angelini 7.11.1989 appl. 28.1.1988 . Formulation s eye drops 50 mg 10 ml 5 as hydrochloride D Remydrial...
Koh 1
acid ethyf ester II DOS 2 149 070 Boehringer Mannh. appl. 1.10.1971 . FR-appl. 2 154 739 Boehringer Mannh. appl. 29.9.1972 D-prior. 1.10.1971, 22.6.1972 . Formulations drg. 200 mg f. c. tabl. 200 mg s. r. drg. 400 mg tabl. 200 mg D Azufibrate Azupharma Befibrate Henning Bezacur Hexal Cedur Boehringer Mannh. Lipox TAD Pegradin Berlin-Chemie Sklerofibrate Merckle F B fizal Boehringer Mannh. Squibb I Bezalip Boehringer Mannh. Bibrocathin Bismucatebrol Use antisePtic RN 6915-57-7 MF c6HBiBr403 MW...
Benzyl alcoholatc R02AD
Alcoholum benzylicum Phenylcarbinolum Use dis,nfectam'local anesthetlc rn 100-51-6 MF c7hso MW 108.14 einecs 202-859-9 LD5 324 mg kg M, i.V. 1360 mg kg M, p.o. 53 mg kg r, i.V. 1230 mg kg r, p.o. cn benzenemethanol Ullmanns Encykl. Tech. Chem., 4. Aufl., Vol. 8, 437. Formuladon s amp. 1 , 2 cream 1 sol. 1 g 100 g D Spitacid Henkel -comb. numerous combination preparations Sudocrem Tosara -comb. I Borocaina Schiapparelli RN 120-51-4 MF C14H1202 MW 212.25 EINECS 204-402-9 LD5 1400 pL kg M, p.o....
Info Tbe
US 3 198 804 Bristol-Myers 3.8.1965 appl. 6.1.1965 prior. 25.1.1963 . Formulation s amp. 250 mg, 500 mg, 1 g tabl. 50 mg as potassium salt D Penplenum Bristol wfm F Versapen Allard wfm i Dicloeta Lusopharma -comb. with dicloxacillin wfm Etadipen Ghimas -comb. with dicloxacillin wfm Versaclox Bristol -comb. with dicloxacillin wfm Versapen Bristol wfm J Natacillin Banyu USA Versapen Bristol wfm RN 7247-57-6 MF C 8H22BrN03S MW 412.35 LD5I1 3576 mg kg R, p.o.
Cooh Gpr
US 2 611 786 Mallinckrodt 1952 appl. 1950 prior. 21.7.1948 . Wallingford et al. J. Am. Chem. Soc. JACSAT 74, 4365 1952 . Kretzer Ber. Dtsch. Chem. Ges BDCGAS 30, 1944 1897 . Formulation s vial. 250 mg ml, 500 mg ml F. Vasurix Guerbet wfm J Diaginol Banyu wfm Pyelokon-R GB Diaginol May amp Baker USA Cystocon Mallinckrodt Mallinckrodt wfm wfm wfm Salpix Ortho wfm Acetylcholine chloride atc soiebo9 Use parasympathomimetic, miotic, vasodilator peripheral rn 60-31-1 MF c7h16c1n02 MW 181.66 einecs...
Info Ndl
US 3 091 569 Mead Johnson . 28.5.1963 appl. 26.8.1960 . US 3 184 505 Mead Johnson 18.5.1965 appl. 18.6.1962 . Smith, H.A. Gorin, G. J. Org. Chem. JOCEAH 26, 820 1961 . ammonium salt mucolysis of bronchial mucus by nebulization DOS 2 305 271 Bristol-Myers appl. 2.2.1973 USA-prior. 3.2.1972 . Acemuc betapharm Fluimucil-100 -200 Zambon numerous combination and generic preparations F Broncoclar Oberlin Codotussyl Whitehall Euronac Europhta Exomuc Bouchara amp. 300 mg as monosodium salt cps. 200 mg...
Cooh Q
Gericke, R. Rogalski, W. Arzneim.-Forsch. ARZNAD 29 I , 362 1979 . DOS 2 427 224 E. Merck appl. 6.6.1974 . DOS 2 345 402 E. Merck appl. 8.9.1973 . DOS 2 621 011 E. Merck appl. 12.5.1976 . GB 1 436 989 E. Merck appl. 5.9.1974 D-prior. 8.9.1973, 6.6.1974 . US 4 153 693 E. Merck 8.5.1979 D-prior. 8.9.1973, 6.6.1974 . GB 1 539 158 E. Merck appl. 11.5.1977 D-prior. 12.5.1976 . Trade Name s D Refosporin E. Merck wfm RN 25953-19-9 MF CJ4Hi4N804S3 MW 454.52 EINECS 247-362-8 LDjo-. 3 g kg M, i.v. RN...
Info Pns
Ullmanns Encykl. Tech. Chem., 4. Aufl., Vol. 8, 237. Formulation s amp. 10 mg ml, 50 mg ml, 100 mg ml tabl. 65 mg Trade Name s D Methylenblau Vitis Collyre Bleu Laiter Mictasol Bleu Martin- amp Johnson-MSD - Pastilles Monl on Blu Meti Formulario Naz. Urolene Blue Star Toulade -comb. USA Urised PolyMedica - Pharmaceut. Stilla Phygi ne -comb. comb. Blu Di Meti Scfm rn 56-04-2 MF c,h6n2os MW 142.18 einecs 200-252-3 LD50 1500 mg kg r, p.o. cn 2,3-dihydro-6-methyl-2-thioxo-4 li -pyrimidinone List,...
Info Lvm
methyl 3ap7a-diacetoxy-12ot-hydroxycholanate I methyl 3a,7a-diocetoxy-12-oxocholanote II 1. h2n-nh2 .h2o. ho- oh - 200 c methyl 3a,7a-diocetoxy-12-oxocholanote II Fieser, L.F. Rajagopalan, S. J. Am. Chem. Soc. JACSAT 72, 5530 1950 . Hauser, E. et al. Helv. Chim. Acta HCACAV 43, 1595 1960 . Hofmann, A.F. Acta Chem. Scand. ACHSE7 17, 173 1963 . Sato, Y. Ikekawa, N. J. Org. Chem. JOCEAH 24, 1367 1959 . DOS 2 302 744 Union International appl. 20.1.1973 GB-prior. 20.1.1972 . DE 2 404 102 Schering AG...
Info Cmd
diphenylmethyl 6-benzomidapenicillonote diphenylmethyl 6-epi-benzomidopenicillonate S-oxide II
Info Jbk
Engelhardt, A. Arzneim.-Forsch. ARZNAD 11, 217 1957 . Formulation s sol. 14.5 mg 5 ml numerous combination v gt 1111 preparations wfm Pertix-Hommel Liquidum GB Cam Rybar wfm Hommel wfm I Pertix Bonomelli Farm. -comb. wfm RN 2090-89-3 MF C13H20N2O2 MW 236.32 CN 2- 2-methylpropyl amino ethanol 4-aminobenzoate ester RN 553-68-4 MF C13H20N2O2 HCl MW 272.78 LD50 36 mg kg M, i.V. 28 mg kg R, i.v.
Info Qwe
US 2 096 744 Schering Corp. 1937 D-prior. 1932 . DRP 698 796 Schering AG appl. 1932 . b Inhoffen, H.H. Z hlsdorff, G. Ber. Dtsch. Chcm. Ges. BDCGAS 74, 1911 1941 . US 2 361 847 Schering Corp. 1944 D-prior. 1937 . Ullmanns Encykl. Tech. Chem., 3. Aufl., Vol. 8, 657. The Merck Index, 12th Ed., 630 1996 . alternative syntheses GB 485 388 Lab. Fran . de Chimioth rapie appl. 1936 . US 2 225 419 Schering Corp. 1940 D-prior. 1937 . US 3 128 238 Lilly 7.4.1974 appl. 14.9.1962 . Eder, U. et al. Chem....
Iii Vne
a US 3 019 260 American Cyanamid 30.1.1962 prior. 13.5.1959 . DE 1 082 905 American Cyanamid appl. 3.11.1958 USA-prior. 5.11.1957 . b US 3 200 149 Pfizer 10.8.1965 prior. 23.5.1960 . DAS 1 793 556 Pfizer appl. 19.5.1961 USA-prior. 23.5.1960 . DE 1 298 522 Pfizer appl. 23.5.1961 USA-prior. 23.5.1960 . Blackwood, R.K. et al. J. Am. Chem. Soc. JACSAT 85, 3943 1963 . stereospecific hydrog nation o metacycline with diaceto triphenylphosphine rhodium II complex to doxycycline DAS 2 554 524 Pfizer...
AA3oA
3-dimethylamino- II phenol sodium salt US 2789 891 Osterr. Stickstoffwerke 1957 A-prior. 1954 . Formulation s collyre0.25 , 0.5 , 1 Trade Name s D Tosmilen Lentia wfm GB Tosmilen Astra wfm J Tosmilen Chugai F Tosmilene Chibret wfm Tosmilen Sinclair wfm USA Humorsol Merck
Info Rfz
DOS 2 009 555 Sogeras appl. 28.2.1970 GB-prior. 3.3.1969 . US 3 987 042 Auclaire M. et al. 19.10.1976 prior. 17.8.1973 . Formulation s syrup 1.25 mg ml, 2.5 mg ml tabl. 5 mg Trade Name s D Metaplexan Rh ne-Poulenc Rorer 1977 F Butix Pierre Fabre Rorer 1976 I Primalan Rh ne-Poulenc Rorer 1985
Ix
a DE 1 232 150 Merck amp Co. appl. 16.3.1962 USA-prior. 22.3.1961, 5.1.1962 . DAS 1 620 014 Merck amp Co. appl. 29.6.1966 USA-prior. 30.6.1965 . DEI 620 030 Merck amp Co. appl. 16.3.1962 USA-prior. 22.3.1961, 5.1.1962 . DE 1 620 031 Merck amp Co. appl. 16.3.1962 USA-prior. 22.3.1961, 5.1.1962 . DE 1 643 463 Merck amp Co. appl. 12.10.1967 USA-prior. 13.10.1966, 14.8.1967 . US 3 161 654 Merck amp Co. 15.12.1964 appl. 11.6.1963 prior. 22.3.1961 . b Yamamoto, H. Chem. Pharm. Bull. CPBTAL 16, 17...
Levothyroxineatc H03AA01
RN 51-48-9 MF Cl5HnI4N04 MW 776.87 EINECS 200-101-1 CN RN 55-03-8 MF C15H10I4NNaO4 MW 798.85 EINECS 200-221-4 LD50 20 mg kg R, i.p. 50 mg kg R, s.c. diiodo thyronine cf. dextrothyronine synthesis Nahm, H. Siedel, W. Chem. Ber. CHBEAM 96, 1 1963 . DE 1 067 826 Hoechst appl. 1955 . DE 1 077 673 Hoechst appl. 1958 . alternative syntheses from L-tyrosine via l-A'-acetyl-3,5-diiodotyrosine ethyl ester DE 1 064 529 G. Hillmann appl. 1956 . DE 1 065 855 G. Hillmann appl. 1956 . US 2 803 654 Baxter...
Info Dwa
GB 191 008 E. Layraud 1922 F-prior. 1921 . US 1 856 792 Eli Lilly 1932 prior. 1929 . Formulation s tabl. 15 mg, 30 mg, 50 mg, 100 mg Jalonac Rohm Pharma -comb. wfm Metrotonin Temmler -comb. wfm Carlytene amobarbital Dedieu -comb. wfm Meteoxane Gallier -comb. wfm Nardyl Vernin -comb. wfm Noctadiol Millot-Solac -comb. wfm Supponoctal Houde -comb. wfm Tensophoril Synlab -comb. wfm Visceralgine comprimes Riom -comb. wfm Sodium Amytal Flynn Tuinal Flynn -comb. 1 Amobarb Tariff. lntegrativo J Amytal...
H Cja
Pd-MgO, Al203, 25 C or I2, Nal, H20, H2S04 Pechmann, H. Burkard, E. Ber. Dtsch. Chem. Ges. BDCGAS 33, 3590 1900 . Hoyce, D.S. et al. J. Org. Chem. JOCEAH 20, 1681 1955 . Momose, T. et al. Heterocycles HTCYAM 30, 789 1990 . DE4 328 228 BASF prior. 23.8.1993 . US 5 569 769 BASF 29.10.1996 D-prior. 23.8.1993 . DE3 918 979 BASF prior. 10.6.1989 . EP 366 328 Nissan Chem. Ind. appl. 17.10.1989 J-prior. 26.10.1988 . Fomulation s vials, 1 g ml 1.5 ml Trade Name s Use antitussive, respiratory analeptic...
Koh
Ghosh, T.N. Roy, A.C. J. Indian Chem. Soc. JICSAH 22, 39 1945 . Formulation s eye drops 0.3 Trade Name s D dura Ultra durachemie - Idrilsine Winzer -comb. I Fotofil Intes -comb. comb. Tele-Stulln Stulln -comb. Adenosylmethionine Methioninyl adenylate SAM Use antirheumatic degenerative RN 29908-03-0 MF C15H22N605S MW 398.44 EINECS 249-946-8 CN inner salt Preparation by fermentation of Saccharomyces cerevisiae baker yeast with addition of l- or dl-methionine, lyse of cells with ethyl acetate and...
Info Dle
US 3 399 192 Science Union 27.8.1968 GB-prior. 22.4.1964 . preparation of l- 2-phenylethyl -4-piperidone Beckett et al. J. Med. Pharm. Chem. JMPCAS 1, 37, 51 1959 . Elpern et al. J. Am. Chem. Soc. JACSAT 80, 4916 1958 . Dutta, A.K. Xu, C Reith, M.F.A. J. Med. Chem. JMCMAR 39 3 , 749 1966 . Janssens, F. et al. J. Med. Chem. JMCMAR 28 12 , 1925 1985 . Formulation s cps. 40 mg, 80 mg suppos. 40 mg, 80 mg Trade Name s F Pneumorel Euth rapie as I Espiran ICT Fluiden Lafare hydrochloride Fenspir...
Info Ncm
Reichstein, T. Gr ssner, A. Helv. Chim. Acta HCACAV 17, 311 1934 . Ullmanns Encykl. Tech. Chem., 3. Aufl., Vol. 18, 223 ff. Kirk-Othmer Encycl. Chem. Technol., 2. Ed. 15SWA8 , Vol. 2, 1963-1971 , p. 747 ff. Formulation s amp. 562 mg eff. tabl. 1 g powder 1 g tabl. 50 mg, 200 mg, 500 mg
H Kkc
DE 1 293 774 Sience-Union et Cie., Soc. Fran . de Recherche M dicale appl. 22.6.1965 USA-prior. 27.7.1964 . GB 1 078 186 Sience-Union et Cie., Soc. Fran . de Recherche M dicale appl. 16.6.1965 USA-prior. 27.7.1964 . EP 2 531 146 R. J. Wurtman et al. USA-prior. 16.6.1987 . medical use for intermittent carbohydrate craving EP 53 175 J. R.Wurtman et al. appl. 15.6.1981 USA-prior. 16.6.1980 . hydrochloride wfm F Isomeride Ardix as hydrochloride wfm hydrochloride wfm I Glypolix Servier as...
Oh Trj
US 2 770 649 Robins 1956 prior. 1955 . Yale, H.L. et al. J. Am. Chem. Soc. JACSAT 72, 3710 1950 . Formulation s amp. 100 mg ml tabl. 250 mg, 500 mg, 750 mg tabl. USA 325 mg, 400 mg in comb, with aspirin D Ortoton Bastian-Werk GB Robaxin Shire Miowas Wassermann F Lumirelax Jumer Sa - I Miowas 1FI wfm wfm Carxin Kanto Methocabal Zeria Methocal Daiko Nichirakishin S Nichiiko Ohlaxin Ohta USA Robaxin Robins RN 18652-93-2 MF C14H18N203 MW 262.31 RN 60634-69-7 MF C14H17N2Na03 MW 284.29 --- c c - I...
Cooh Kva
US 2 823 164 Nat. Res. Dev. Corp. 1958 prior. 1953 . US 2 993 928 Glaxo 25.7.1961 GB-prior. 15.1.1957 . GB 671 070 Glaxo appl. 1949 . Formulations tabl. 0.005 mg, 0.02 mg, 0.025 mg, 0.05 mg, 0.1 mg vial 0.01 mg ml, 0.1 mg ml D Thybon Henning Berlin Thyrotardin Henning Berlin numerous combination preparations F Cynomel Marion Merrell GB Tertroxin Link I Titre Teofarma J Thyronamin Takeda Thyronine Taisho USA Cytomel Jones Medical Industries as sodium salt Cytomel SmithKline Beecham as sodium...
K 0
a US 3 163 645 Ciba 29.12.1964 appl. 25.9.1964 prior. 9.4.1958 . Stevens, G. de et al. Experientia EXPEAM 14, 463 1958 . b US 3 164 588 Merck amp Co. 5.1.1965 GB-prior. 19.6.1959 . US 3 025 292 Merck amp Co. 13.3.1962 prior. 26.11.1958 . purification US 3 043 840 Merck amp Co. 10.7.1962 appl. 14.10.1959 . Formulation s tabl. 12.5 mg, 25 mg, 50 mg, 100 mg
Info Iva
FR 870 714 Geigy appl. 1941 Palestine-prior. 1940 . DE 756 489 Geigy appl. 1941 Palestine-prior. 1940 . D Medomin Geigy wfm F Medomine Geigy wfm GB Medomin Geigy wfm RN 372-66-7 MF CgH19NO MW 145.25 EINECS 206-758-0 RN 543-15-7 MF QH NO-HCl MW 181.71 EINECS 208-837-5 LDS0 900 mg kg M,i.p.
Info Cry
Formulation s cream 4 oz. lotion 4 oz. Aegrosan Opfermann Busala Pharma Selz Ceolat Solvay Arzneimittel Dimeticon-ratiopharm ratiopharm Espumisan BerlinChemie ILIO-Funktion Kautabletten Robugen Meteosan Novartis sab simplex Parke Davis Symadal Chauvin ankerpharm Rennie Deflantine Labs. Roche Nicholas SA -comb. numerous combination preparations GB Infacol Pharmax numerous combination preparations I Mylicon Parke Davis Olio Silic Tariff. Integrativo Polisilon Midy -comb. Silisan Lipha -comb. J...
Info Hin
Reference s Budesinsky-Protiva, 235. Willgerodt, C Ber. Dtsch. Chem. Ges. BDCGAS 14, 2451 1881 . US 2 462 389 Socony-Vac Oil 1949 prior. 1946 . Trade Name s D Givalex Norgine F Alodont Warner-Lambert -comb. Angispray Monot -comb. Balsamorhinol Janssen -comb. Ciella RPR Cooper -comb. Eludril Inava -comb. Givalex Nagine Pharma -comb. Liquifilm Allergan -comb. Optrex Etris -comb. GB Cerumol L.A.B. -comb. Eludril Chefaro -comb. Monphytol L.A.B. -comb. I Abiostil Deca -comb. Antipulmina Lisapharma...
Info Xzn
US 2 876 233 Gr nenthal 3.3.1959 prior. 29.10.1956 . Formulations cream 5 ointment 5 as hydrochloride D Myco-Jellin Gr nenthal -comb. with fluocinolone acetonide wfm RN 57-15-8 MF C4H7C130 MW 177.46 EINECS 200-317-6 CN 1,1,1 -trichloro-2-methyl-2-propanol
Dexchlorpheniramineatc R06AB02
RN 25523-97-1 MF C16HI9C1N2 MW 274.80 EINECS 247-073-7 CN RN 2438-32-6 MF C16H19C1N2 C4H404 MW 390.87 EINECS 219-450-6 LDW 28 mg kg M, i.V. 189 mg kg M, p.o. 267 mg kg R, p.o. GB 834 984 Scherico appl. 4.7.1958 USA-prior. 4.3.1958 . US 3 030 371 L. H. Walter 17.4.1962 appl. 4.3.1958 . US 3 061 517 Schering Corp. 30.10.1962 prior. 16.2.1962 . Formulation s drg. 6 mg tabl. 2 mg Shionogi USA Baylarmine Bay wfm Polaronil Byk Essex f Celestamine Schering- I Plough as meleate Polaramine...
Demeclocycline
RN 127-33-3 MF C21H21C1N208 MW 464.86 EINECS 204-834-8 LD50 79 mg kg M, i.V. gt 6.75 g kg R, p.o. CN 4S- 4a,4aoc,5aa,6 , 12aa -7-chIoro-4- dimethyl l-dioxo-2-naphthacene carboxamide ATC D06AA01 J01AA01 Use antibiotic RN 64-73-3 MF C21H21C1N208 HCl MW 501.32 EINECS 200-592-2 LD50 275 mg kg M, i.v. 2150 mg kg M, p.o. 94 mg kg R, i.V. 2372 mg kg R, p.o. From fermentation solutions of a Streptomyces aureofaciens mutant. US 2 878 289 American Cyanamid 17.3.1959 prior. 28.5.1956 . US 3 012 946...
Ci Ycs
CH 200 248 Roche 1937 . sulfonate US 3 031 457 R. Charonnat, J. Chareton, A. Boune 24.4.1962 F-prior. 28.9.1955 . alternative syntheses Buchman, E.R. J. Am. Chem. Soc. JACSAT 58, 1803 1936 . Sawa, Y. Ishida, T. Yakugaku Zasshi YKKZAJ 76, 337 1956 . amp. 0.8 as ethanedisulfonate cps. 192 mg, 300 mg syrup 320 mg 10 ml tabl. 500 mg D Distraneurin Astra F H mineurine D bat wfm GB Heminevrin Astra Chlomethocillin Use antibiotic RN 1926-49-4 MF CnH aCl2N205S MW 433.31 EINECS 217-657-6 CN acid RN...
H Rhe
FR-M 1 658 Science-Union appl. 4.4.1961 MC-prior. 5.11.1960 . Formulation s cps. 20 mg, 60 mg s. r. cps. 60 mg tabl. 20 mg, 40 mg as hydrochloride Trade Name s D Ponderax Boehringer Ing. wfm F Pond ral Biopharma as Pesos Valeas hydrochloride ' Pond ral Servier GB Ponderax Servier wfm USA Pondimin Robins I Dimafen Stroder
Cooh Toe
EP 140 116 Hokuriku appl. 15.9.1984 J-prior. 19.9.1983, 12.3.1984, 18.6.1984 . DE 3 433 924 Hokuriku appl. 15.9.1984 J-prior. 19.9.1983, 12.3.1984, 18.6.1984 . US 4 528 287 Hokuriku 9.7.1985 appl. 17.9.1984 J-prior. 19.9.1983, 12.3.1984, 18.6.1984 . isotonic solution for i.v. administration oras ophthalmic or nasal solution US 4 780 465 Hokuriku 25.10.1988 appl. 20.5.1987 J-prior. 14.1.1987 . DOS 3 715 918 Hokuriku appl. 13.5.1987 J-prior. 14.1.1987 . synthesis of acid DE 3 031 767 Kyorin appl....
Hci Ekf
racemate resolution with L -tartaric acid a Wilkinson, R.G. et al. J. Am. Chem. Soc. JACSAT 83, 2212 1961 . Wilkinson, R.G. et al. J. Med. Pharm. Chem. JMPCAS 5, 835 1962 . US 3 176 040 American Cyanamid 30.3.1965 prior. 2.6.1960 . BE 600 640 American Cyanamid appl. 24.2.1961 USA-prior. 2.6.1960, 20.12.1960 . BE 613 545 American Cyanamid appl. 6.2.1962 USA-prior. 23.1.1962 . racemate resolution q -2-aminobutanol with tartaric acid US 3 553 257 American Cyanamid 5.1.1971 prior. 16.9.1966 ....
H Oh
Kanai, T. et al. Chem. Pharm. Bull. CPBTAL 18, 2569 1970 . alternative syntheses Walwick, E.R. et al. Proc. Chem. Soc., London PCSLAW 1959, 84. Doerr, L.L. Fox, J.J. J. Org. Chem. JOCEAH 31, 1465 1967 . Ruyle, W.V. Shenn, T.Y. J. Med. Chem. JMCMAR 10, 331 1967 . Kugawa, K.K. Ichino, M. Tetrahedron Lett. TELEAY 1970, 867. The Merck Index, 11th Ed., 663 Rahway 1991 . Formulation s amp. 10 mg, 500 mg as hydrochloride Trade Name s J Cyclo-C Kohjin as hydrochloride rn 9046-56-4 MF unspecified MW...
O Djk
Ullmanns Encykl. Tech. Chem., 4. Aufl., Vol. 23, 414. Formulation s amp. 113.2 mg ml as disodium salt eye drops 1.7 mg ml D Fluorescein-L sung 1 0 intraven s Inj.-L sung Alcon Fluoreszein 0,15 Thilo Augentropfen Thilo Pan creolau ryl-Test Temmler Thilorbin Alcon GB Minims Fluorescein Sodium Chauvin Minims lignocaine and fluorescein Chauvin -comb. Geymonat as laurate J Fluor Tobishi-Santen Fluores Showa Yakuhin Fluorescein sodium Kobayashi Fluorescite Alcon D10AA01 S01BA07 S01CB05 Use...
Info Ply
Thuillier, G. Rumpf, P. Thuillier, J. C. R. Hebd. Seances Acad. Sci. COREAF 249, 2081 1959 . FR 398 M Centre Nat'l. Recherche Sci., appl. 15.4.1959 . Formulation s amp. 250 mg, 500 mg, 2 g as hydrochloride drg. 200 mg, 500 mg f. c. tabl. 100 mg, 250 mg D CERUTIL Isis Pharma F Helfergin Promonta Lundbeck Isis Pharma as GB hydrochloride Lucidril Lipha Sant as hydrochloride Lucidril Reckitt amp Colman wfm Lucidril Bracco wfm Lucidril Dainippon Meclon Toho Mecroeat Hishiyama Proseryl Funai
I Jla
N.N-dimethyl-N'- 2 -pyridyl ethylene-diamine RN 54-05-7 MF CliiH2ftON3 MW 319.88 EINECS 200-191-2 LD50 21.6 mg kg M, i.v. 311 mg kg M, p.o. 60 mg kg R, i.v. 330 mg kg R, p.o. CN RN 50-63-5 MF C18H26C1N3 2H3P04 MW 515.87 EINECS 200-055-2 LDjo 500 mg kg M, p.o. sulfate 1 1 RN 132-73-0 MF CISH26C1N3 H2S04 MW 417.96 EINECS 205-077-6 sulfate 1 1 monohydrate RN 6823-83-2 MF C18HMC1N3 H204S H20 MW 435.97 dihydrochloride RN 3545-67-3 MF C18H26C1N3 2HC1 MW 392.80 EINECS 222-592-1 2,5-dihydroxybenzoate...
Info Ijq
DE 1 108 215 Merck AG appl. 22.12.1959 . Schubert, K. Biochem. Z. BIZEA2 327, 507 1956 . DE 1 026 748 Philips Gloilampenfabrieken appl. 1956 NL-prior. 1955 . US 2 228 491 Winthrop 1941 D-prior. 1938 . DE 1 492 177 A. Schumacher appl. 3.11.1965 . Formulation s cps. 0.125 mg, 0.5 mg drops 0.1 syrup 0.25 mg ml F Calcamine Wander wfm GB A.T. 10 Sanofi Winthrop I A.T. 10 Bayer-Yoshitomi RN 821-33-0 MF C8HIK03 MW 162.23 EINECS 212-475-3 CN 4,4'-oxybi s 2-butanol FR 1 267 084 M. A. Joulty appl. 1960 ....
Cooh Wjv
acid ethyl 2-chlaro-6-ethyl-iso-nicotinote It